The present study found that HER-2 expression was significantly higher in breast cancer tissues compared with adjacent tissues, which was positively correlated with SLN metastasis of breast cancer. Acknowledgments We send our sincere gratitude to the reviewers for their kind comments. The present study is conducted to investigate the correlation of HER-2 protein expression with SLN metastasis and prognosis in breast cancer so as to test if HER-2 is a potential marker in sentinel lymph node SLN metastasis and prognosis of breast cancer. CI, confidence interval; RR, risk ratio; —, no value. Logistic regression model was used to analyze multiple factors that were shown to exert an effect on SLN metastasis in univariate analysis. The primer sequences were shown in Table 1. Furthermore, it was shown that there was a close correlation between HER-2 overexpression and nodal metastasis because of the boost of HER-2 on cell proliferation, migration, and metastasis in breast cancer [ 30 ].
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Breast Cancer HER2 Status
From January to June , female patients with primary breast cancer undergoing radical mastectomy or modified radical mastectomy in the Department of Surgical Oncology of Ningbo Yinzhou No. Enumeration data were expressed as percentage or rate and tested by chi-square test. China Find articles by Xiao-Dong Yuan. In accordance with the criteria of Chinese Pathological Classification of Tumors, the histopathological classification of breast cancer was divided into 31 invasive patients, 17 noninvasive patients, and nonspecific invasive patients. In addition, the present study showed that the expression of HER2 in breast cancer tissues was correlated with the expression levels of ER and PR.
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Breast Cancer to get more details about these tests. The breast cancer tissues and corresponding adjacent tissues of all included patients were obtained. Journal List Biosci Rep v. The SLN metastasis was classified into the positive expression if the staining was positive, otherwise it was regarded as the negative expression remove of false positive [ 20 ]. Answer From Timothy J. Accessed March 3,
Description:These treatments are so effective that the prognosis for HER2-positive breast cancer is actually quite good. HER-2 overexpression has been proved to be a strong biochemical marker for breast cancer prognosis [ 40 ]. Thus, the up-regulation of HER-2 was linked to a poorer prognosis in breast cancer [ 42 ]. The authors declare that there are no competing interests associated with the manuscript. We would enlarge sample size in future studies to examine the clinical value of HER-2 in breast cancer. This receptor has a close correlation with cellular growth, apoptosis, proliferation, differentiation, angiogenesis, and aggression by regulating various signaling pathways [ 11 ].